Space Rats were mutant rats which dwelled in the Pirate Ship in the Qwark Vid-Comic Booty is in the Eye of the Beholder. Their behavior was a somewhat like that of the Anklebiters of the original Ratchet & Clank (2002 game), except that they were a bit more faster. One single hit was enough to take care of them. Since the story about Captain Darkwater is true, it is possible Space Rats originate somewhere in the Polaris Galaxy. In all the Ratchet & Clank Future saga, especially in Ratchet & Clank Future: A Crack in Time and Ratchet & Clank: Into the Nexus, villainous characters such as Lord Vorselon often refer to Ratchet as "Wretched Space Rat!" This suggests that Space Rats are common throughout the universe and a common insult to a Lombax.
- Ratchet & Clank: Up Your Arsenal (first appearance)