The Psycho Qwarks were enemies encountered by Ratchet on the nightmarish realm of Dreamtime. As their name suggests, the Psycho Qwarks were crazed copies of Captain Qwark. They wore a doctor's attire and were armed with a chainsaw. They were usually found in groups, although they were would sometimes attack alone. Unlike other copies of Captain Qwark, the Psycho Qwarks had red eyes and would not speak unless they were attacked.
- The Psycho Qwarks were merely products of Ratchet's imagination. Ironically, these were the only known versions of Qwark capable of scaring Ratchet.
- The Psycho Qwarks would throw their chainsaws instead of swinging them. After throwing their chainsaw, they would get a new one from their first-aid kit.