Mutant Sandflies were small silver-grayish flies that lived in the Tabora desert and attacked Ratchet if they saw him. They were probably closely related to the Mutant Firefly. They traveled in huge swarms, and attacked with their sharp pincers. Tougher and stronger than their distant cousins, the Mutant Sandfly packed a mean punch, if they were not disposed of quickly. They were also faster than Mutant Fireflies, and would attack swiftly and quickly.

Ratchet could use the Heavy Lancer or HK22 Gun to take out the swarms fast. Also, they could also spawn infinitely from special creatures, scattered around the Taborian desert.