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The ExtermiBots, also known as Mist Troopers [citation needed], were neutral enemies that Ratchet and Clank encountered in Blackwater City. They had been sent to planet Rilgar to get rid of the Amoeboid infestation. Often attacking in groups, they carried a small gun which shot out a small cloud of green gas. If Ratchet had the O2 Mask equipped, the green mist had no effect. The fact that they are neutral means that they attack anything in sight, including Ameboids. The ExtermiBots will attack Ratchet if there are not any Amoeboids around, which might imply that a curfew is in effect in Blackwater City and that their orders are to attack anything or anyone on the streets.

In Ratchet & Clank: Up Your Arsenal, the ExtermiBots return in the second episode of the Captain Qwark Vid-Comic Series Arriba Amoeba again on planet Rilgar this time it appears that they were on the Amoeboids' side, out to get Qwark and Qwark alone. However, this may not be true.